Modified food grade microorganism for treatment of inflammatory bowel disease
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United States of America Patent
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Jun 17, 2014
Grant Date -
Nov 8, 2012
app pub date -
Jan 5, 2011
filing date -
Jan 7, 2010
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Abstract
The present invention relates to microorganisms that express, or have attached to their surface, a TNFα binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNFα and therefore reducing the content of free TNFα and alleviating its pro-inflammatory effects in the gut. The invention also relates to the use of such microorganisms as medicament in the treatment of inflammatory bowel disease.
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