Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II
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United States of America Patent
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Jun 10, 2014
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Apr 18, 2006
filing date -
Apr 18, 2005
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Abstract
This application is based, inter alia, on the discovery of a binding interaction between the Hn-33 hemagglutinin polypeptide of the type A Clostridium botulinum neurotoxin complex and synaptosomal proteins, including synaptotagmin II (Syt II). Methods of screening for compounds that modulate, e.g., increase or decrease, this interaction are provided. Also provided are compositions and methods for targeting compounds to neuronal and cancer cells by coupling the compounds to Hn-33 or biologically active Hn-33 variants.
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