Pegylated albumin and uses thereof

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United States of America Patent

PATENT NO 8741832
APP PUB NO 20090298746A1
SERIAL NO

11921064

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Abstract

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The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, wherein the PEG is a maleimide PEG, an alkylamide PEG, an iodoacetamide PEG, a p-nitro thio-phenyl PEG, a vinyl sulfone PEG, or a mixed disulfide PEG; and PEGylated albumins and PEGylated hemoglobins comprising polyethylene glycol (PEG) attached to a thiolated amino group of albumin or hemoglobin, wherein the amino group is thiolated using dithio sulfo succinimidyl propionate (DTSSP) or dithiosuccinimidyl propionate (DTSP) or dithiobispropionimidate. The invention also provides methods of preparing PEGylated hemoglobins and PEGylated albumins comprising a) reacting hemoglobin or albumin with a thiolating agent and with a PEGylating agent, and b) capping unPEGylated reactive thiols of hemoglobin or albumin with N-ethyl maleimide.

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Patent Owner(s)

Patent OwnerAddress
ALBERT EINSTEIN COLLEGE OF MEDICINE1300 MORRIS PARK AVENUE BRONX NY 10461

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Acharya, Seetharama A Cresskill, US 16 121
Manjula, Belur N Cresskill, US 14 197

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