T cell receptor display
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United States of America Patent
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Jun 3, 2014
Grant Date -
May 6, 2010
app pub date -
Oct 21, 2009
filing date -
Nov 9, 2002
priority date (Note) -
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Abstract
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
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