Constructs and methods for the production and secretion of polypeptides
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United States of America Patent
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May 27, 2014
Grant Date -
Jun 2, 2011
app pub date -
Jul 30, 2009
filing date -
Jul 31, 2008
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Abstract
Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.
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