Compositions and methods for inhibition of fucosyltransferase and xylosyltransferase expression in plants
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United States of America Patent
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May 6, 2014
Issued Date -
N/A
app pub date -
Jan 17, 2007
filing date -
Jan 17, 2006
priority date (Note) -
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status (Latency Note)
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Abstract
Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant RNAi construct that provides for the inhibition of expression of α1,3-fucosyltransferase (FucT) and β1,2-xylosyltransferase (XylT) in a plant. Use of these RNAi constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a “humanized” N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the G0 glycoform, are also provided.
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International Classification(s)
- 2007 Application Filing Year
- C07H Class
- 2326 Applications Filed
- 871 Patents Issued To-Date
- 37.45 % Issued To-Date
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- 0 Citation Count
- C07H Class
- 0 % this patent is cited more than
- 11 Age
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| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Nov 6, 2025 |
