Acetaminophen assay
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United States of America Patent
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May 6, 2014
Grant Date -
Nov 29, 2012
app pub date -
Jul 9, 2012
filing date -
Apr 28, 2008
priority date (Note) -
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Abstract
In general, the present invention provides a reliable assay for the quantitative determination of p-aminophenol in an aqueous sample. More particularly, the present invention provides a rapid enzyme-based assay for the quantitative determination of acetaminophen in a sample. The assay employs a xylenol chromophore and a catalyst that is preferably a weak oxidizer. The assay provides reliable results in the presence or absence of N-acetylcystiene (NAC) and can therefore be used to monitor acetaminophen levels during NAC treatment. Methods and kits for determining acetaminophen concentration in an aqueous sample are also provided.
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