Macrocyclic cysteine protease inhibitors and compositions thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8710178
APP PUB NO 20110021434A1
SERIAL NO

12446053

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF CANTERBURY20 KIRKWOOD AVENUE UPPER RICCARTON CHRISTCHURCH 8041 NEW ZEALAND
LINCOLN UNIVERSITYLINCOLN 7647
DOUGLAS PHARMACEUTICALS LIMITEDLINCOLN AUCKLAND 0610

International Classification(s)

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  • 2007 Application Filing Year
  • A61K Class
  • 9805 Applications Filed
  • 5595 Patents Issued To-Date
  • 57.07 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2007200820092010201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abell, Andrew David Christchurch, NZ 4 15
Aitken, Steven Geoffrey Christchurch, NZ 6 19
Bickerstaffe, Roy Canterbury, NZ 3 13
Coxon, James Morriss Christchurch, NZ 3 13
Duncan, Joanna Kimberley Christchurch, NZ 2 13
Jones, Matthew Alan Christchurch, NZ 5 13
Klanchantra, Mutita Christchurch, NZ 2 13
Lee, Hannah Yun Young Christchurch, NZ 2 13
McNabb, Stephen Brian Christchurch, NZ 2 13
Morton, James David Canterbury, NZ 3 13
Muir, Matthew Stewart Canterbury, NZ 3 13
Neffe, Axel Thomas Christchurch, NZ 6 15
Nikkel, Janna Marie Christchurch, NZ 3 13
Robertson, Lucinda Jane Goodricke Canterbury, NZ 2 13
Stuart, Blair Gibb Christchurch, NZ 3 13

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  • A61K Class
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1767499999127813872291511752101 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0250500750100012501500175020002250250027503000325035003750400042504500475050005250

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11.5 Year Payment $7400.00 $3700.00 $1850.00 Oct 29, 2025