TC-83-derived alphavirus vectors, particles and methods
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United States of America Patent
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Apr 29, 2014
Grant Date -
Feb 3, 2011
app pub date -
Jul 6, 2010
filing date -
May 18, 2004
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Abstract
The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.
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