Targeting cancer stem cells with DR5 agonists

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United States of America Patent

PATENT NO 8703712
APP PUB NO 20130004521A1
SERIAL NO

13634401

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Abstract

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Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more DR5/DDX3/IAP complexes in or from the cancer stem cells. Also provided is a method of killing cancer stem cells in a subject and a method of reducing the risk of cancer recurrence in a subject.

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Patent Owner(s)

Patent OwnerAddress
LOYOLA UNIVERSITY CHICAGO2160 SOUTH FIRST AVENUE MAYWOOD IL 60153

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buchsbaum, Donald J Alabaster, US 29 355
Foreman, Kimberly Clarendon Hills, US 1 3
Lobuglio, Albert F Birmingham, US 13 117
Zhou, Tong Birmingham, US 235 2173

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