deficient in endogenous secreted protease
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United States of America Patent
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Apr 22, 2014
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Dec 13, 2010
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Dec 14, 2009
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Abstract
The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins in which the host cell, Pichia pastoris, has been genetically modified so that the gene for endogenous secreted subtilisin Sub2 protease is completely or partially inactivated.
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