Second generation low oxygen affinity pegylated hemoglobins as oxygen-carrying plasma expanders
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United States of America Patent
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Apr 15, 2014
Grant Date -
Aug 26, 2010
app pub date -
Mar 12, 2008
filing date -
Mar 13, 2007
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Abstract
Provided are hemoglobins having at least two chemical modifications that lower oxygen affinity, hemoglobins chemically modified by the addition of glyceraldehyde-3-phosphate, and hemoglobins having at least two specific chemical modifications. PEGylated versions of these hemoglobins are also provided, as are certain tetraPEGylated and diPEGylated hemoglobins. Methods of modifying a hemoglobin are additionally provided, as are methods of making a hemoglobin. Pharmaceutical compositions and blood substitutes using these hemoglobins are further provided, as are methods of treating a subject using these pharmaceutical compositions and blood substitutes.
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