Nucleic acid size detection method
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United States of America Patent
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Apr 15, 2014
Grant Date -
Jul 1, 2010
app pub date -
Apr 11, 2007
filing date -
Oct 5, 2006
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Abstract
The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequence. In particular aspects, an expansion or reduction of tandem repeat sequences can be detected. In further aspects, carriers and individuals afflicted with fragile X syndrome or other diseases associated with tandem repeats can be distinguished from normal individuals.
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