Rationally designed, synthetic antibody libraries and uses therefor
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United States of America Patent
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Apr 8, 2014
Grant Date -
Jul 16, 2009
app pub date -
Sep 12, 2008
filing date -
Sep 14, 2007
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Abstract
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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