Methods of utilizing the arrestin-2/STAM-1 complex as a therapeutic target
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United States of America Patent
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Apr 8, 2014
Grant Date -
Mar 8, 2012
app pub date -
May 25, 2011
filing date -
May 26, 2010
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Abstract
Methods of utilizing the arrestin-2/sTAM-1 complex as a therapeutic target. The methods include treating cells of a living organism to mediate an interaction between arrestin-2 and STAM-1 adapter protein molecules, wherein the interaction is characterized by the arrestin-2 adapter protein molecule directly binding to the STAM-2 adapter protein molecule. Pharmacological agents can be identified for therapeutic uses by determining whether the pharmacological agent disrupts the interaction between the arrestin-2 and STAM-1 adapter protein molecules.
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