Methods of using proteinacious channels to identify pharmaceutical treatments and risks, and treatments resulting therefrom
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United States of America Patent
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Apr 1, 2014
Grant Date -
Oct 28, 2010
app pub date -
Jun 14, 2010
filing date -
Oct 31, 2008
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Abstract
Methods and therapeutic strategies utilizing proteinacious channels in lipid membranes of mammalian cells. The methods entail administering a pharmaceutical to a lipid membrane of a mammalian cell, and then determining the effect of the pharmaceutical on the electrophysiology of at least one proteinacious channel of the lipid membrane, wherein the proteinacious channel is a Kv7 potassium channel and/or a L-type calcium channel of an airway smooth muscle cell (ASMC). The method can be used to identify pharmaceuticals that may be used to treat asthmatic and other bronchospastic conditions that can lead to airway obstruction, or to perform drug screening to assess potential risk of pharmaceuticals.
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