Polypeptoid pulmonary surfactants
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United States of America Patent
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Mar 18, 2014
Grant Date -
Oct 11, 2012
app pub date -
Feb 13, 2012
filing date -
Feb 16, 2000
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Abstract
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
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