Polymer conjugates of K-252A and derivatives thereof

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United States of America Patent

PATENT NO 8673347
APP PUB NO 20080193517A1
SERIAL NO

12064461

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Abstract

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The present invention relates to novel polymer conjugates of K-252a and derivatives thereof and to their use for the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of kinase-associated pathologies. In particular, the present invention relates to the prevention, alleviation and treatment of HMGB1-associated pathologies. The invention relates to the use of the novel polymer conjugates of K-252a and derivatives thereof in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of a) neurological disorders, neuropathies and neurodegenerative disorders of the central and peripheral nervous system; b) dermal pathologies, in particular dermal pathologies associated with an excessive keratinocyte proliferation, in particular psoriasis; and c) NGF-related pain. More specifically, the present invention relates to a polymer conjugate of K-252a and derivatives thereof, wherein the polymer is polyethylene glycol or methoxy-polyethylene glycol formula (I).

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Patent Owner(s)

  • CREABILIS THERAPEUTICS S.P.A.;CREABILIS THERAPEUTICS S.R.L.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bagnod, Raffaella Bollengo, IT 2 56
Barone, Domenico Turin, IT 6 113
Beccaria, Luca Ivrea, IT 5 59
Bertarione, Rava Rossa Luisa Pavon Canavese, IT 5 71
Fumero, Silvano Ivrea, IT 8 77
Lorenzetto, Chiara Villafranca Piemonte, IT 7 73
Mainero, Valentina Ivrea, IT 11 67
Marconi, Alessandra Reggio Emilia, IT 5 65
Oderda, Cecilia Vésenaz, CH 1 56
Pincelli, Carlo Sassuolo, IT 6 65
Traversa, Silvio Palazzo Canavese, IT 10 67

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