Biocatalyst for production of D-lactic acid

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United States of America Patent

PATENT NO 8669093
APP PUB NO 20070065930A1
SERIAL NO

10573813

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Abstract

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A method for producing D-lactic acid in high yield, and to provide a method for producing D-lactic acid with high selectivity, in which optical purity is high and a by-product organic acid is small. In one aspect, a microorganism, wherein activity of pyruvate formate-lyase (pfl) is inactivated or decreased, and further activity of Escherichia coli-derived NADH-dependent D-lactate dehydrogenase (ldhA) is enhanced, is cultured to efficiently produce D-lactic acid. With regard to a method for enhancing ldhA activity, by linking, on a genome, a gene encoding ldhA with a promoter of a gene which controls expression of a protein involved in a glycolytic pathway, a nucleic acid biosynthesis pathway or an amino acid biosynthesis pathway, suitable results are obtained compared to the method for enhancing expression of the gene using an expression vector. A microorganism in which a dld gene is substantially inactivated or decreased is cultured to produce high quality D-lactic acid with reduced concentration of pyruvic acid.

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Patent Owner(s)

Patent OwnerAddress
MITSUI CHEMICALS INC5-2 HIGASHI-SHIMBASHI 1-CHOME MINATO-KU TOKYO 1057122 ?1057122

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abe, Reiko Mobara, JP 4 4
Araki, Tadashi Mobara, JP 77 615
Higashi, Yosuke Mobara, JP 23 219
Kawashima, Miyuki Mobara, JP 7 41
Mimitsuka, Takashi Kamakura, JP 22 81
Miyake, Hitoki Mobara, JP 8 10
Mochizuki, Daisuke Mobara, JP 98 884
Morishige, Takashi Mobara, JP 25 112
Oikawa, Toshihiro Mobara, JP 35 331
Sawai, Hideki Kamakura, JP 26 197
Takahashi, Hitoshi Mobara, JP 152 1913
Tokuda, Junko Mobara, JP 10 63
Wade, Mitsufumi Mobara, JP 1 0

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