Indenoisoquinolinone derivatives, manufacturing method and medical use thereof
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United States of America Patent
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Mar 4, 2014
Grant Date -
Apr 4, 2013
app pub date -
Dec 16, 2009
filing date -
Oct 22, 2009
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Abstract
Indenoisoquinolinone derivatives (I), the manufacturing method and the medical use thereof, which belong to pharmaceutical chemistry and organic chemistry field, are disclosed. These compounds can be used for treating several medical symptoms related to postmenopausal syndrome, uterine fibers deterioration and aortic smooth muscle cells proliferation, especially ER-(+) depend breast cancer. Meanwhile, these compounds can also be used for treating glioma and lung cancer, and have inhibiting effect on tumor metastasis effect on tumor metastasis.
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