Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
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United States of America Patent
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Feb 25, 2014
Grant Date -
Jun 16, 2011
app pub date -
Feb 7, 2011
filing date -
Sep 7, 2007
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Abstract
Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.
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