Antifolate combinations
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United States of America Patent
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Feb 25, 2014
Grant Date -
Jun 7, 2012
app pub date -
Dec 7, 2011
filing date -
Dec 7, 2010
priority date (Note) -
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Abstract
The present invention provides combinations of active agents, such combinations comprising one or more antifolate compounds. The particularly can include methotrexate and one or more further antifolate compounds. In specific embodiments, the combinations are useful for treating certain conditions, such as rheumatoid arthritis. The invention also provides articles useful to provide the combinations in desirable dosage forms and combinations. The combinations further may be useful in the treatment of further conditions, including abnormal cell proliferation, inflammatory diseases, asthma, and arthritis.
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