Binding of aggregated forms of proteins
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United States of America Patent
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Feb 25, 2014
Grant Date -
Jan 12, 2012
app pub date -
Jul 14, 2011
filing date -
Feb 28, 2002
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Abstract
Aggregating proteins such as IgG, are bound selectively in the presence of the non-aggregated protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.
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