Combination therapy with MDM2 and EFGR inhibitors
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United States of America Patent
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Feb 25, 2014
Grant Date -
Jun 21, 2012
app pub date -
Jul 21, 2011
filing date -
Jan 6, 2010
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Abstract
Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic anti-proliferative or anti-apoptotic effect compared to administration of one agent alone.
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