Compositions and methods for treatment of the side-effects associated with administration of cancer chemotherapeutic agents
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United States of America Patent
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Feb 18, 2014
Grant Date -
Sep 27, 2012
app pub date -
Apr 13, 2012
filing date -
Mar 12, 2008
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Abstract
A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine and orotate. The administration of a protein pump inhibitor decreases systemic absorption of orotate and the administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species.
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