Peptide probe for rapid and specific detection of β-amyloid aggregation
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United States of America Patent
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Feb 11, 2014
Grant Date -
Jan 12, 2012
app pub date -
Aug 13, 2010
filing date -
Aug 14, 2009
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Abstract
A peptide probe that generates fluorescence signals rapidly upon recognition of various Aβ aggregates without significant perturbation of samples. The present peptide probes display an increase in fluorescence signals upon coincubation with Aβ oligomers, but neither monomeric/dimeric species nor fibrils. The detection can occur within an hour or two without any additional sample preparation and incubation steps.
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