Polymer-conjugated glycosylated neublastin
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United States of America Patent
Stats
-
Feb 4, 2014
Grant Date -
Dec 13, 2012
app pub date -
Mar 21, 2012
filing date -
Apr 18, 2003
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The following class of molecule is disclosed: a dimer containing a first neublastin polypeptide and a second neublastin polypeptide, wherein: (a) at least one of the polypeptides is glycosylated; (b) at least one of the polypeptides is conjugated at its N-terminus to a water-soluble synthetic polymer; and (c) neither of the polypeptides is conjugated to a water-soluble synthetic polymer at a position other than the N-terminus. Such dimers possess the biological activity of wild-type neublastin while displaying enhanced serum half-life and enhanced potency relative to wild-type neublastin.
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Patent Citation Ranking
- 2 Citation Count
- A61K Class
- 21.20 % this patent is cited more than
- 11 Age
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