Formulation and use thereof
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United States of America Patent
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Feb 4, 2014
Grant Date -
Oct 14, 2010
app pub date -
Jun 18, 2010
filing date -
Jun 3, 2002
priority date (Note) -
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Abstract
Provided are liquid pharmaceutical formulations comprising nicotine in any form for administration essentially to the lungs being acidified and/or alkalized by buffering and/or pH regulation providing for a tmax of nicotine in arterial blood of a subject within a short period of time after administration. The administration is preferably accomplished by spraying an aerosol into the oral cavity for further distribution essentially into the lungs. Methods for manufacturing the formulation is also disclosed, as are uses of the formulation in therapy, such as therapy for treating addiction to tobacco.
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