Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof
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United States of America Patent
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Jan 28, 2014
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Jun 20, 2013
app pub date -
Mar 31, 2011
filing date -
Jun 8, 2010
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Abstract
Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).
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