Production method for adefovir dipivoxil

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United States of America Patent

PATENT NO 8637669
APP PUB NO 20110207930A1
SERIAL NO

13119538

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Abstract

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The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.

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Patent Owner(s)

Patent OwnerAddress
CJ HEALTHCARE CORPORATIONJUNG-GU SEOUL 100-400

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bang, Seong Cheol Nonsan-si, KR 3 2
Cho, Il Hwan Seoul, KR 33 132
Do, Choi Kwang Anyang-si, KR 1 0
Hong, Hye Suk Seongnam-si, KR 3 5
Lee, Min Kyoung Yongin-si, KR 9 19
Lee, Si Beum Yongin-si, KR 4 2
Lee, Yong Tack Seoul, KR 3 2
Oh, Da Won Seoul, KR 4 1
Yoon, Myeong Sik Yongin-si, KR 6 3

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