Fusion antibodies for HIV therapy
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United States of America Patent
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Jan 28, 2014
Grant Date -
May 17, 2012
app pub date -
Nov 11, 2011
filing date -
Nov 12, 2010
priority date (Note) -
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Abstract
Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.
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