Genetic vasectomy by overexpression of PRML-EGFP fusion protein in spermatids
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United States of America Patent
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Jan 21, 2014
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Jul 12, 2012
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Aug 26, 2010
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Aug 28, 2009
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Abstract
The present invention provides a genetically-modified non-human animal whose somatic and germ cells contain an exogenous gene encoding a recombinant fusion protein, wherein the presence, and expression, of said recombinant fusion protein renders said genetically-modified non-human animal sterile. Tools for generating such sterile genetically-modified non-human animal as well as methods of use thereof are also provided.
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