Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation
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United States of America Patent
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Jan 14, 2014
Grant Date -
Jul 5, 2012
app pub date -
Aug 12, 2010
filing date -
Nov 1, 2000
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Abstract
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
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