Continuous process for microspheres production by using expanded fluids
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United States of America Patent
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Jan 14, 2014
Grant Date -
Aug 12, 2010
app pub date -
Jul 25, 2008
filing date -
Jul 27, 2007
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Abstract
The invention concerns a process for the continuous treatment of an emulsion and/or a micro-emulsion assisted by an “expanded liquid” for the production of micro- and/or nano-particles or micro- and/or nano-spheres containing one or more active ingredients. In particular, a liquid solvent expanded by compressed or supercritical CO2 is contacted with an O/W emulsion, or alternatively a W/O emulsion or multiple emulsions, formed by an external phase that is itself a liquid expanded by compressed CO2. The expanded liquid forms a solution with the dispersed phase of the emulsion and extracts it inducing the formation of the desired particles of the dissolved compounds.
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