Multi-antigenic alphavirus replicon particles and methods
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United States of America Patent
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Dec 31, 2013
Grant Date -
Sep 4, 2008
app pub date -
May 6, 2008
filing date -
Dec 13, 2002
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Abstract
Viral replicon selected nucleic acid expression libraries are useful for analyzing multiple antigens associated with a parasite, pathogen or neoplasia or for preparing immunogenic compositions for generating immune responses specific for the parasite, pathogen or neoplasia. Alphavirus replicon particles representative of the nucleic acid expression library are preferred. The nucleic acid library can be a random library, or it can be prepared after a selection step, for example, by differential hybridization prior to cloning into the replicon vector.
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