Inhibitors of Akt activity

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United States of America Patent

PATENT NO 8614221
APP PUB NO 20120004240A1
SERIAL NO

13255785

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fan, Weiming Chapel Hill, US 15 52
Haxell, Thomas F N Morrisville, US 1 1
Jenks, Matthew G Durham, US 7 51
Kawanishi, Nobuhiko Moriya, JP 17 60
Lee, Shuliang Durham, US 1 3
Liu, Hao Raleigh, US 555 2317
Malaska, Michael J Chapel Hill, US 2 10
Moore,, III Joseph A Raleigh, US 8 16
Ogino, Yoshio Tsukuba, JP 31 269
Onozaki, Yu Yokohama, JP 21 133
Pandi, Bharathi Cary, US 8 10
Peel, Michael R Chapel Hill, US 5 16
Sakamoto, Toshihiro Moriya, JP 47 594
Siu, Tony Brookline, US 30 268

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