Peptides, compositions and uses thereof

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United States of America Patent

PATENT NO 8614187
APP PUB NO 20120295851A1
SERIAL NO

13530550

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Abstract

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Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent relaxation of arterial smooth muscle, while causing less potent contraction of ileal smooth muscle. It may be used treatment of diseases of the cardiovascular system and in promotion of angiogenesis.

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Patent Owner(s)

Patent OwnerAddress
THE QUEEN'S UNIVERSITY OF BELFASTBELFAST BT7 1NN

International Classification(s)

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  • 2012 Application Filing Year
  • A61K Class
  • 11964 Applications Filed
  • 9694 Patents Issued To-Date
  • 81.03 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201220132014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Tianbao Belfast, GB 4 9
Hirst, David Belfast, GB 14 160
O'Rourke, Martin Belfast, GB 3 9
Shaw, Christopher Belfast, GB 28 163
Walker, Brian Belfast, GB 67 786

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