Antibodies against APRIL as biomarkers for early prognosis of lymphoma patients
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United States of America Patent
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Dec 17, 2013
Grant Date -
Jun 16, 2011
app pub date -
Sep 22, 2006
filing date -
Sep 26, 2005
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Abstract
The invention relates to antibodies directed against APRIL (A Proliferation Inducing TNF Ligand, also known as TALL-2), in particular the monoclonal antibody Aprily-2, hybridoma cells producing monoclonal antibody Aprily-2, and the use of a combination of an antibody against membrane-anchored APRIL and Aprily-2 in the diagnosis of B cell lymphoma resistance to treatment and the prognosis of clinical development of Diffuse Large B-Cell (DLBCL) lymphoma from high risk patients (>60 years and International Prognostic Index >2). An amino acid sequence GTGGPSQNGEGYP called Stalk, useful in the preparation of antibodies, is described.
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