Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
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United States of America Patent
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Dec 17, 2013
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Mar 8, 2012
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Sep 1, 2011
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Sep 2, 2010
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Abstract
The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
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