Real time electrophysiological testing of agents of interest for treatment of amyloid-type diseases

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United States of America Patent

PATENT NO 8609361
APP PUB NO 20100311102A1
SERIAL NO

12682230

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Abstract

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This invention corresponds to an in vitro method that employs an electrophysiology technique; in particular, an embodiment of the patch-clamp technique in its perforated type, which will allow us evaluating the neurotoxic capacity of protein structures associated to the generation of neurodegenerative diseases. It addition, it allows evaluating potential pharmacologic capacities of candidate molecules (drugs) in order to prevent, treat, or cure the said diseases. The invention involves the use of peptides that cause neurodegenerative diseases in order to form a spontaneous perforated recording that only occurs with peptides in the patch clamp glass pipette.

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Patent OwnerAddress
UNIVERSIDAD DE CONCEPCIONBARRIO UNIVERSITARIO EDIFICIO EMPREUDEC CONCEPCION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hernandez, Aguayo Luis Gerardo Concepcion, CL 1 0
Martinez, Opazo Carlos Roberto Concepcion, CL 1 0
Rivera, Parodi Jorge Luis Concepcion, CL 1 0

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