Antigen surrogates in autoimmune disease
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United States of America Patent
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Dec 10, 2013
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app pub date -
Apr 10, 2012
filing date -
Jan 10, 2011
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Abstract
The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the concomitant removal of T-cells associated with autoimmune disorders.
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