Bioreactor for quantification of headspace VOC content from cultures
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United States of America Patent
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Dec 3, 2013
Grant Date -
Mar 10, 2011
app pub date -
Sep 3, 2010
filing date -
Sep 4, 2009
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Abstract
A bioreactor for sampling the headspace above cells includes a glass reactor vessel having an interior space and a plurality of valves operatively coupled to the interior space of the glass reactor vessel. The bioreactor includes a sample holder configured to reside in the interior space. The interior space includes a charge of air with a known composition of volatile organic gases and, in some instances, doped with carbon dioxide. The sample holder may hold cells, bacteria, or viruses. The headspace may be sampled after incubation to determine the VOC content or content of specific VOC constituents. Examples include acetaldehyde and hexanaldehyde.
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