Microtablets for drug delivery
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United States of America Patent
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Dec 3, 2013
Grant Date -
Mar 14, 2013
app pub date -
Nov 8, 2012
filing date -
Sep 12, 2011
priority date (Note) -
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Abstract
Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
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