Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (VEGF)
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United States of America Patent
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Nov 26, 2013
Grant Date -
Oct 28, 2010
app pub date -
Oct 26, 2008
filing date -
Oct 25, 2007
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Abstract
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
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