Antibodies for detecting or monitoring a malignant plasma cell disease
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United States of America Patent
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Nov 26, 2013
Grant Date -
Jul 21, 2011
app pub date -
Jan 21, 2011
filing date -
Jan 27, 2005
priority date (Note) -
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Abstract
The present invention is directed to antibodies having specificity for a heavy chain class at the same time as having specificity for a first light chain. Such antibodies can be used in a method of detecting or monitoring a malignant plasma cell disease comprising determining in a sample the ratio between the relative amounts of immunoglobulins having:
- (i) a heavy chain class bound to λ light chains; and(ii) immunoglobulins having the same heavy chain class but bound to κ light chains. More particularly, in one embodiment the ratio is determined after measuring the relative amounts of the respective immunoglobulins using:an antibody, or a fragment thereof, having specificity for a heavy chain class at the same time as having specificity for a first light chain in combination with either:(i) an antibody, or a fragment thereof, having specificity for the heavy chain class at the same time as having specificity for the second light chain; or(ii) an antibody, or fragment thereof, having specificity for the heavy chain and a further antibody, or fragment thereof, having specificity for the second light chain.
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