Mycobacterial mutants inducing IL-12
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United States of America Patent
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Nov 26, 2013
Grant Date -
Jun 7, 2012
app pub date -
Mar 10, 2008
filing date -
Mar 19, 2007
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Abstract
Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant mycobacterium, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.
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