Peptide vaccine using mimic molecules of amyloid β peptide
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United States of America Patent
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Nov 19, 2013
Grant Date -
Dec 30, 2010
app pub date -
Oct 22, 2008
filing date -
Oct 25, 2007
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Abstract
This invention is intended to discover a peptide that induces production of an antibody specific for an abnormal amyloid β peptide from mimic peptides of the amyloid β peptide and to utilize the same as a vaccine or immunogen. This invention relates to a pharmaceutical composition containing a peptide consisting of 8 to 30 amino acid residues, wherein the peptide comprises at least one of an amino acid sequence represented by formula (I): Tyr-Gly-Thr-Lys-Pro-Trp-Met (SEQ ID NO: 28) (I), and an amino acid sequence represented by formula (II): Leu-Asp-Ile-Phe-Ala-Pro-Ile (SEQ ID NO: 29) (II); or a conjugate of such peptide and a carrier.
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