Humanized recombinant uricase and mutants thereof

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United States of America Patent

PATENT NO 8586535
APP PUB NO 20120269795A1
SERIAL NO

13504065

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Abstract

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The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant unease and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.

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Patent Owner(s)

Patent OwnerAddress
LUNAN PHARMACEUTICAL GROUP CORPORATIONSHANDONG PROVINCE 276006
SHANDONG NEW TIME PHARMACEUTICAL CO LTD273400 SHANDONG CITY OF LINYI PROVINCE FEIXIAN COUNTY NORTH RING ROAD NO 1 LINYI CITY SHANDONG PROVINCE 273400

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fan, Kai Jiulongpo Chongqing, CN 24 300
Hu, Chunlan Jiulongpo Chongqing, CN 5 4
Ma, Xuefeng Jiulongpo Chongqing, CN 5 9
Mei, Xiang Jiulongpo Chongqing, CN 12 5
Zhang, Chun Jiulongpo Chongqing, CN 123 1997

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