Method of identifying a compound for preventing and/or treating an autoimmune disease

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United States of America Patent

PATENT NO 8581022
APP PUB NO 20110004953A1
SERIAL NO

12749593

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of identifying a compound for preventing and/or treating an autoimmune disease is described which comprises obtaining a (BTLA−/−) NKT cell from a non-human animal, contacting the (BTLA−/−) NKT cell ex vivo with a test compound, in the presence of an antigen, measuring a response of the (BTLA−/−) NKT cell to the antigen, comparing the response of the (BTLA−/−) NKT cell to the antigen with a response of a (BTLA−/−) NKT cell in control assay, and selecting the compound that reduces the response of the (BTLA−/−) NKT cell in the presence of an antigen compared to a response of a (BTLA−/−) NKT cell in the control assay. Other methods of identifying a compound for preventing and/or treating an autoimmune disease are also described.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITYCHIBA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Oya, Yoshihiro Chiba, JP 1 3
Watanabe, Norihiko Chiba, JP 14 109

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