Metformin-cysteine prodrug
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United States of America Patent
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Nov 12, 2013
Grant Date -
Oct 20, 2011
app pub date -
Apr 15, 2011
filing date -
Apr 16, 2010
priority date (Note) -
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Abstract
A metformin-cysteine prodrug. It is believed that the prodrug of the present invention will transport in the LAT1 and LAT2 transporter system. Because the LAT1 and LAT2 transporters are important and effective transporters of amino acids in both the small intestine and colon, it is believed that the LAT-transportable prodrugs of the present invention will be effectively absorbed both in small intestine and in the colon. The increased absorption window provided by the present invention should result in highly sustained plasma concentrations of metformin, thereby increasing the effectiveness of the medication and allowing for a single daily dose.
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